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Immunoglobulin Products - Quick Guide


Products NZBS provides human immunoglobulin concentrate of IgG antibodies prepared from pooled plasma donations in three formulations:
  • for intravenous use
  • for subcutaneous use
  • for intramuscular use
 Immunoglobulin pre-approval form


NBA Guidelines
Australian NBA IVIG Guideline


NHS Guidelines (2021)
English NHS IVIG Guideline
Intravenous products There are several different intravenous products available in New Zealand. The different products have different rates for administration. Please check you have the correct infusion rate for the specific IVIg product you are administering.
  • Intragam®P
    a 6% solution prepared from New Zealand donors' plasma. IntragamP is being phased out and replaced nationally with 10% IVIG products. The phase is staged. See this document for a timeline.
  • PrivigenNZ
    a 10% solution prepared from New Zealand donor plasma and manufactured by the same company that made IntragamP, CSL Behring. ProvigenNZ is being rolled out nationally and replaces IntragamP.
  • Privigen
    a 10% solution manufactured in exactly the same way and the same plant as as PrivigenNZ but from European and American donor plasma. New Zealand is approximately 90% self-sufficient as a country for IVIG. For the remainder, we have Privigen.
  • Gamunex
    a 10% IVIG solution manufactured by Grifols. This is only for patients who cannot tolerate Privigen or PrivigenNZ. We have a small stock of Gamunex. This is available only after discussion with a New Zealand Transfusion Medicine Specialist.
Subcutaneous products There are currently two subcutaneous products available in New Zealand. Please check administration instructions before use.
  • HizentraNZ
    a 20% solution, is prepared from New Zealand donors' plasma by the same manufacturer as Privigen NZ, CSL Behring. This is the new default subcut immunoglobulin product.
  • Hizentra
    As New Zealand is not entirely self-sufficient for subcutaneous immunglobulin, we also have Hizentra, manufactured in exactly the same way as HizentraNZ but from European and American donor plasma.
Intramuscular product The only non-specific intramuscular product is Normal Immunoglobulin, prepared from New Zealand donors' plasma. This is usually for hepatitis A and measles prophylaxis but is occasionally used as a replacement immunoglobulin for hypogammaglobulinaemia.
Hyperimmune products Hyperimmune immunoglobulins are also pooled immunoglobulin concentrates but with a known level of activity against a named virus or protein. Hyperimmune immunoglobulins prepared from New Zealand donors' plasma are Anti-D, Hepatitis B Immunoglobulin, Tetanus Immunoglobulin and Zoster Immunoglobulin. Other hyperimmune immunoglobulins are available as Section 29 products.
Datasheets
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